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Hepatic: Mild increase in liver enzymes (reversible after drug withdrawn), hepatotoxicity, overdosage of paracetamol is the leading cause of acute liver failure.
Hematologic: Thrombocytopenia, pancytopenia, leucopenia, neutropenia.
Skin: Paracetamol associated with Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN) and acute generalized exanthematous pustulosis (AGEP).
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